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肝舒康冲剂防治二甲基亚硝胺致大鼠肝纤维化的实验研究
Experimental Study on the Effect of Ganshukang Granule on Treating Fiberized Liver in Rats Leaded by Dimethylnitrosamine
【摘要】 目的:研究肝舒康冲剂对肝纤维化的防治作用。方法:采用二甲基亚硝胺(DMN)所致大鼠肝纤维化模型,研究肝舒康冲荆对大鼠血清透明质酸(HA)和Ⅲ型前胶原(PC Ⅲ)及病理组织形态学的影响。结果:肝舒康冲剂能降低肝纤维化血清学指标HA、PC Ⅲ数值,改善肝组织病理损害,明显优于对照组(P<0.05~0.01)。结论:肝舒康冲剂具有良好的预防和治疗肝纤维化效果。
【Abstract】 Aim: To study the effect of Ganshukang granule (GSK) on preventing and treating experimental fiberized liver in rats. Method: The animal model of fiberzed liver in rats was set up with DMN. The effect of GSK (medicine to be taken affter being mixed with boiling water, wine, etc) on HA. PC I and pathology of fiberized liver were observed. Result: The result showed that GSK is effective for treating fiberized liver in rats. The HA. PC I and liver cells were improved much better than that in control group (P<0. 05-0. 01). Couclusion: GSK have antifiberized function obviously.
【Key words】 Ganshukang Granule Dimethylnitrosamine (DMN) Fiberzed Liver Rats;
- 【文献出处】 中西医结合肝病杂志 ,Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases , 编辑部邮箱 ,2000年04期
- 【分类号】R285
- 【被引频次】8
- 【下载频次】97