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γ—GTⅡ单克隆抗体在肝癌诊断中的应用

Application of γ -GTⅡ McAb in Diagnosis of Hepatic Carcinoma.

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【作者】 付平平曹纯章魏景艳

【Author】 FU Ping-Ping; CAO Chun-zhang; WEI Jing-yan; The Third Clinical College, Norman Bethune University of Medical Sciences, Changchun, 130031 china

【机构】 白求恩医科大学第三临床学院!中日联谊医院中心实验室吉林长春130031吉林省临床检验中心

【摘要】 目的探讨γ-谷氨酰转换酶同工酶Ⅱ(γ-GT 0Ⅱ)单克隆抗体(McAb)对肝癌的诊断。方法采用ELISA法、AFP 放射免疫法对154例患者血清检测。结果 ELISA法检测患者血清γ-GTⅡ含量,原发性肝癌、转移性肝癌阳性率分别为 93%、89%,其他肿瘤均为阴性;AFP放射免疫法检测,原发性肝癌、转移性肝癌阳性率分别为80.4%、57.0%,其他肿瘤阳性率 为 0%-10%,病毒性肝炎、肝硬化阳性率为 80%以上。结论 应用 ELISA法检测血清 γ-GTⅡ是目前一种诊断肝癌的非常有 价值的检测方法。

【Abstract】 Objective To study r-GTⅡ McAb in diagnosis of hepatic carcinoma. Methods Serum of 154 cases were studied by using ELISA and AFP radioimmunity. Results The positive rate of primary hepatic carinoma and metastatic hepatic carcinoma were 93% and 89%, respectively and it was zero in other carcinoma groups, by using ELISA. The positive rate of AFP was 80.4% and 57% in primary hepatic carinoma and metastatic hepatic carcinoma respectively, 10% in other carcinoma groups by AFP. The poritive rate is 86% and 80% in hepatitivirosis and cirrhosis respectively. Conclusion r- GTⅡ serum of patients was examined by using ELISA. It is a valuable method in diagnosis of hepatic carcinoma.

  • 【文献出处】 中国实验诊断学 ,CHINESE JOURNAL OF LABORATORY DIAGNOSIS , 编辑部邮箱 ,2000年05期
  • 【分类号】R735.7
  • 【下载频次】25
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