【摘要】 目的　了解重症肌无力患者自身抗体的产生与细胞因子的关系。方法　采用免疫酶点方法检测 2 2例重症肌无力患者外周血AChRAb分泌细胞和IFN γ分泌细胞。结果　重症肌无力患者外周血AChRAb分泌细胞和IFN γ分泌细胞均高于正常对照组 ,AChRAb和IFN γ之间呈高度正相关性 ,不同亚型之间两种分泌细胞差异均无显著性。结论　重症肌无力患者体内有IFN γ分泌细胞增高 ,IFN γ与AChRAb的相关性提示IFN γ可能对重症肌无力患者自身抗体的产生有促进作用。更多还原

【Abstract】 Objective To investigate and verify the regulatory effect of secreting IFN γ on autoimmune antibody of myasthenia gravis( MG). Methods IFN γ secreting cells and AChRAb secreting cells were detected in 22 cases of MG patients by ELISPOT assay. Results Both IFN γsecreting cells and AChRAb secreting cells in MG were higher than that in control.There were good relations between IFN γ secreting cells and AChRAb secreting cells.There was no significant diffenrences between subtypes of MG. Conclusion IFN γ may play an important role in MG.更多还原