【摘要】 采用免疫组织化学方法 ,结合计算机图形分析技术 ,研究一次或长期给予抗抑郁药后大鼠不同脑区C- FOS免疫反应性。结果显示 :1一次给药后额叶皮质 ,扣带回 ,嗅结节岛 ,纹状体四个部位的免疫反应阳性细胞数显著增加 ;2长期给药组额叶皮质 ,乳头体核 ,杏仁核和纹状体四个部位的 C- FOS免疫反应阳性细胞数显著增加 ;3不同抗抑郁药作用的部位有差异。不同抗抑郁药能使大鼠脑不同区域的 c- fos表达增强 ,可能涉及抗抑郁药的分子作用机制。更多还原

【Abstract】 To investigate the expression of c fos gene in the brain of mature male rats after acute and chronic administration of four antidepressant drugs,immunohistochemical and computer mapping technique were used.The results showed that①the fos like immunoreaction (FLI)was increased in the rat frontal cortex,cingulate cortex,islands of Calleja and caudate putamen in the acute group;②the FLI was increased in the rats frontal cortex,mammillary nucleus,amygdaloid nucleus and caudate putamen in the chronic group;③the effects of different antidepressant drugs on the rat brain regions were varied.These suggested that different antidepressant drugs may enhance the expression of c fos in the different regions of rat brain,and it may be involved in the molecular mechanisms of such antidepressant drugs. [更多还原