【摘要】 目的　研究人类白细胞抗原 -DQA1(HLA -DQA1)等位基因对少年型重症肌无力的疾病易感性。方法　采用PCR -RFLP方法 ,对 40例少年型重症肌无力患儿的HLA -DQA1基因进行分型 ,并与健康对照组进行比较。结果　DQA1 0 30 1基因的频率在患病组中升高 ,与健康对照组相比表现出显著性差异 (OR =12 33,P <0 0 1) ;DQA1 0 5 0 1的频率降低。结论　HLA -DQA1 0 30 1基因为少年型重症肌无力的易感基因 ,提示少年型重症肌无力与成人重症肌无力有着不同的免疫遗传机制更多还原

【Abstract】 Objective Research on the disease relationship between polymorphism of HLA-DQA 1 alleles and the susceptibility of juvenile myasthenia gravis(JMG).Methods 40 JMG patients from South China were analyzed and HLA-DQA 1 alleles were determined using PCR-RFLP genotype method,compared with that of health controlled group.Results Frequency of DQA 1*0301 allele increased in JMG patients,which was significantly different compared with the health controls (OR=12 33,P<0 01).Frequency of DQA 1*0501 allele reduced in JMG patients.Conclusion HLA-DQA 1*0301 allele is the susceptible gene of JMG,and JMG is different from adult MG in genetic immune mechanism.更多还原