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细胞凋亡在肝癌浸润转移过程中的状况
The condition of apoptosis in hepatocellular carcinoma infiltration and metastasis
【摘要】 目的 研究肝细胞癌(HCC)凋亡在浸润转移过程中的重要性。方法 采用DNA 原位末端标记法(ISEL)、光镜、电镜,并结合计算机图象分析技术定量检测55例HCC的凋亡发生情况。结果 低分化HCC凋亡指数低于高分化HCC (P<0.05),浸润性和转移性HCC的凋亡指数分别低于非浸润性和无转移HCC(P<0.05和P<0.01)。结论 HCC凋亡指数与肿瘤的某些生物学特性有密切的联系,细胞凋亡的异常改变可能在HCC的浸润转移过程中起重要作用。
【Abstract】 Objective To explore the role of apoptosis in hepatocellular carcinoma(HCC) infiltration and intrahepatic metastasis. Methods Using the in situ DNA end-labeling, light microscopy,electron microscopy in combination with computer-imaging analytic technique, we tested quantitatively apoptotic cells in 55 HCC tissues. Results AI was significantly lower in poorly differentiated HCCs than well differentiated HCCs(P<0.05). Furthermore, HCCs with infiltration and intrahepatic metastasis had a significantly lower AI than those without infiltration and intrahepatic metastasis, respectively (P<0.05 and P<0.01). Conclusion AI has a close relation to some biological characteristics of HCC. The abnormal change in apoptosis may play an important role in the infiltration and intrahepatic metastasis of HCC.
【Key words】 Hepatocellular carcinoma; Apoptosis; Infiltration; Metastasi?;
- 【文献出处】 重庆医科大学学报 ,Acta Universitatis Scientiae Medicinae , 编辑部邮箱 ,2000年04期
- 【分类号】R735.7
- 【被引频次】2
- 【下载频次】38