【摘要】 目的 本文研究了Ｄ－氨基半乳糖盐酸盐溶液的化学稳定性，为该药物的制备、纯化以及实验动物肝细胞损伤模型用药提供必要的稳定性数据。方法 采用恒温加速实验，通过氨基半乳糖含量测定，研究不同ｐＨ条件下本品水溶液的稳定性，并与冰箱贮存样品比较。结果 实验表明，氨基半乳糖盐酸盐溶液ｐＨ值为３比较稳定，调ｐＨ值为７的本品水溶液不稳定，易分解，最多在５℃冰箱中保存５天。试样在加热情况下则迅速变色分解。结论 由于氨基己糖溶液多数不稳定，在各项操作中，应调节其盐酸盐水溶液的ｐＨ值小于７，中性试液只能在冰箱内短期保存。更多还原

【Abstract】 Objective To investigate chemical stability of D-galactosamine hydrochloride solution and give relevant experimental data to making animal model of hepatitis induced by it as well as the preparation and purification of D-GalN HCl. Methods The constant temperature acceleration test was used. The solution concentration was determined on the basis of the determination standard of D-GalN·HCl. The stability of solution was compared with the sample preserved in refrigerator. Results The data of D-GalN·HCl acidic solution (pH=3.0) shows it is stable but its aqueous solution (pH=7.0) unstable. The sample can be stored in refrigerator at 5℃ for 5 days at most, but rapidly decomposed under heating. Conclusion In general, hexosamine aqueous solution is unstable, so the solution in experiments should be pH<7 and can be stored in refrigerator for a short time at pH 7.0.更多还原