【摘要】 研究急性坏死性胰腺炎 (ANP )血液流变学改变及其在病情演进中的作用。方法　检测ANP大鼠的血液流变学指标 ,红细胞脆性及胰腺病理学检查。结果　ANP大鼠全血粘度 ,血浆粘度 ,红细胞压积均显著升高 ,红细胞脆性增加 ;纤维蛋白原降低。结论　ANP时 ,出现显著血液流变学改变 ,后者可能是胰腺进行性坏死 ,病情恶化的主要原因之一更多还原

【Abstract】 Objective To study the hemorrheologic alternation in acute necrotizing pancreatitis(ANP) and its effect in deterioating of ANP. Methods Blood samples were obtained from ANP rats for hemorrheologic examination and erythrocyte osmotic fragility test. Pancreatic tissue was obtained for pathological study. Results Blood viscosity, plasma viscosity, hematocrit, erythrocyte osmotic fragility were significantly elevated, while erythrocyte sedimentation rate and fibrinogen were decreased significantly in ANP rats compared with sham operation group. Conclusions In ANP rats, hemorrheology is altered significantly, which may be one of the important factors in deterioraton the disease.更多还原