【摘要】 目的　探讨p16蛋白与雌激素受体在甲状腺乳头状癌发生发展中的作用及其相关性。方法　应用免疫组化法对 5 0例甲状腺乳头状癌标本进行 p16蛋白及雌激素受体检测。 结果　p16蛋白表达及雌激素受体与甲状腺乳头状癌的组织分化、淋巴结转移及预后有关。结论　p16蛋白表达与雌激素受体水平有助于甲状腺癌的分化及预后的判断更多还原

【Abstract】 HT6”,5”] [WT5”BZ] [WT5”HZ]Objective [WT5”BZ]To observe the action and correlation of p16 and estrogen receptor (ER) in papillary thyroid cancer (PTC). [WT5”HZ]Methods [WT5”BZ]Using immunohistochemical method, the p16 and ER in 50 cases of PTC were detected. [WT5”HZ]Results [WT5”BZ]The expression of p16 and ER was associated with the cellular differentiation, the lymphatic metastasis and prognosis in PTC. [WT5”HZ]Conclusion [WT5”BZ]It is helpful to detect the p16 protein and ER for analyzing the cellular differentiation degree and prognosis in PTC. [HT6,5”] [WT5”HZ]更多还原