【摘要】 目的 :观察恶性淋巴增殖性疾病肿瘤细胞表面 β2 整合素 (CD11a、CD11b)及L 选择素 (CD6 2L)的表达变化及其临床意义。方法 :用流式细胞仪检测 35例初诊或复发急性淋巴白血病 (ALL)、4例慢性淋巴细胞白血病 (CLL)、30例多发性骨髓瘤 (MM)、14例淋巴肉瘤白血病及 2 5例正常人骨髓单个核细胞粘附分子CD11a、CD11b、CD6 2L的表达。结果 :①与正常造血细胞比较 ,CD11b、CD11a在ALL、MM、CLL细胞表达均下降 (P <0 0 1) ,但在淋巴肉瘤白血病细胞表达无明显改变 (P >0 0 5 ) ,CD6 2L在MM、CLL、淋巴肉瘤白血病细胞表达均下降 (P <0 0 5 ) ,但在ALL中表达增强 (P <0 0 5 )。②CD11a在ALL表达明显高于淋巴肉瘤白血病细胞表达 (P <0 0 1) ,CD6 2L在ALL表达明显低于淋巴肉瘤白血病细胞 (P <0 0 1)。③浸润组CD11a在ALL表达高于非浸润组 ,(P <0 0 5 )。④ALL完全缓解组CD11a、CD11b的表达可升至正常范围。结论 :恶性淋巴增殖性疾病肿瘤细胞表面上存在多个粘附分子的表达异常 ,检测粘附分子有助于判断白血病细胞类型及疗效。更多还原

【Abstract】 Objective:To investigate the expression of adhesion molecule including CD11a、CD11b、CD62L on malignant lymophoproliferative disorders and its clinical implications.Methods:Adhesion molecule CD11a、CD11b、CD62L of 35 Acute Lymophocytic Leukemia(ALL)、30 multiple myeloma(MM)、4 Chronic Lymophocytic Leukemia(CLL)、14 lymphosarocoma cell leukemia patients and 25 health people were measured by flow cytometric analysis.Results:①CD11a and CD11b expression were lower on ALL、MM、CLL cells than the normal hematopoietic cells.CD62L expression were lower on CLL、MM、lymphosarocoma cell leukemic cells than the normal hematopoietic cells.②The CD11a was lower expressed on ALL than lymphosarocoma cell leukemic cells,CD62L was higher on ALL than lymphosarocoma cells leukemia.③The expression of CD11a in the ALL invasion group was much higher than that in the noninvasive group(P<0 05) (4)The level of CD11a、CD11b were returned to normal levels at remission.Conclusion:The observations suggest that there are abnormalities in the expression of cell adhesion molecules in malignant lymophoproliferative disorders that may help to identify subtypes and object there treatment effect.更多还原