【摘要】 目的　探讨男性肝硬化失代偿期患者血清性激素及垂体激素水平的变化与肝功能损害程度的关系 .方法　应用放射免疫分析法检测 48例男性肝硬化失代偿期患者血清性激素、睾酮 (T)、雌二醇 (E2 )、垂体激素、促卵泡生成素 (FSH)、促黄体生成素 (LH)及催乳素 (PRL)水平的变化 .结果　患者血清T水平明显降低 (P <0 .0 0 1) ,而E2 (P <0 .0 1) ,PRL(P <0 .0 0 1) ,FSH(P <0 .0 5 )水平均不同程度高于健康组 ,LH水平与对照组无显著差异 .结论　肝硬化失代偿期患者可能存在下丘脑—垂体—性腺轴功能紊乱 .动态观察肝硬化患者血清性及垂体激素水平的变化将有助于临床肝功损害程度的判断及诊断水平的提高 .更多还原

【Abstract】 Objective To explore the relationship between serum levels of sex hormone,hypophyseal hormone and severity of liver dysfunction in the male patients with cirrhosis in the stage of decompensation.Methods Serum components of sex hormone,Testosterone (T),Estradiol (E 2),Hypophyseal hormone,Follicle stimulating Hormone (FSH),Luteinizing Hormone (LH) and Prolactin (PRL) were measured by radioimmunoassay in 48 cases with cirrhosis in the stage of decompensation,then compared with 40 cases normal subjects.Results Serum level of T was significantly decreased ( P <0.001),but E 2 ( P <0.01),PRL ( P <0.001),FSH ( P <0.05) were higher than those of normal subjects.There was no difference of LH ( P >0.05) between patients with cirrhosis and normal controls.Conclusion There may be dysfunction of hypothalamics—pituitary—gonadal axis system in male patients with cirrhosis decompensation.Dynamic analysis of serum levels of sex hormone and hypophyseal hormone is useful for clinical diagnosis of cirrhosis and severity of liver dysfunction.更多还原