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老年肺癌组织学类型、分化及其P53蛋白表达

The Histological classification(Typing) of the elderly lung cancer patients,its differentiation and P53 protein expression

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【作者】 纪正春刘平孙立新宋志杰宋立刚赵晓明胡建功金小平

【Author】 Ji Zhengchun,Sun Lixin,Liu Ping et al (Chengde Medical College,Chengde.067000)

【机构】 承德医学院附属肛肠医院!承德067000承德医学院附属医院

【摘要】 目的研究老年肺癌组织学特点及其P53蛋白的表达。方法肺癌组织学类型按WHO标准进行分类,P53蛋白的表达采 用免疫组化技术。结果老年组肺癌的组织学类型与非老年组不同,差异有显著性(P<0.05);P53蛋白总阳性率为42.86%,两组间差 异没有显著性(P>0.05)。结论老年肺癌的组织学类型有其自己的特点,P53基因在肺癌的发生发展中具有重要意义。

【Abstract】 To study the histological features of elderly lung cancer patients and it’s expression of P53 protein. Methods The histological types were determined according to WHO standard and the immunohistochemical stain was used on the expression of P53 protein. Results There were differences of the histological types between the aged and non-aged patients. The total positive rate of P53 was 42. 86 % with no statistical differences between these two groups. Conclusions the histological types of lung cancer in aged patients have their own features and P53 gene plays an important role in the progression of lung cancer.

  • 【文献出处】 中国老年学杂志 ,Chinese Journal of Gerontology , 编辑部邮箱 ,2000年03期
  • 【被引频次】1
  • 【下载频次】13
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