【摘要】 目的　对雌、孕激素在子宫肌瘤发病中的意义进行探讨。方法　 2 4例子宫肌瘤患者 ,年龄 34～ 51岁 ,分别于手术前后测定血清中雌二醇 (E2 )、孕酮 (PRO)水平 ,计算E2 PRO比值并与 2 0例同年龄段健康体检女性进行对照。另术中取小块肌瘤及正常肌层组织制备成匀浆液测定E2、PRO。测定方法为放射免疫分析法。结果　病例组血清E2水平及E2 PRO比值明显低于对照组 ,PRO变化无意义 ;匀浆液测定肌瘤组织E2含量及E2 PRO比值高于正常肌层组织 ,有显著性差异。结论　子宫肌瘤患者血清E2 PRO比值异常是子宫肌瘤发病的重要因素 ,肌瘤局部组织内E2含量明显升高及E2 PRO比例失调可能是子宫肌瘤发病的直接原因。更多还原

【Abstract】 Objective assess significance of Estradiol(E2)、Progesterone(PRO) level in serum and tissue extraction of patients with uterus myoma.Methods 24 paticnts with utcrus myoma were studied(age of 34～51 years old).Their serum E2、PRO content was determined by RIA pre-and post-operation.E2/PRO ratio was calculated.So did control group of 20 cases.A piece of myoma and normal muscle tissue was taken just the time for operation and this samples were extracted;the E2,PRO level of extraction was detected by RIA.Results The serum E2 content and E2/PRO ratio of uterus myoma group was significant lower than that of control group.E2 content within tissue extraction of myoma was significantly higher than that of normal muscle,as well as the E2/PRO ratio.Conclusion For uterus myoma the abnormal E2/PRO ratio in serum may be the main factor related to that disease,and increase of E2 and imballance of E2/PRO ratio inside myoma may be the direct cause of uterus myoma.更多还原