【摘要】 为评价头孢匹胺治疗细菌性感染的疗效和安全性 ,以头孢匹胺与头孢哌酮随机对照治疗 12 7例患者 ,主要为下呼吸道、尿路等细菌性感染。两药剂量均为每日 2～ 4g,疗程 7～ 14d。头孢匹胺组 6 3例 ,头孢哌酮组 6 4例 ,两组有效率分别为 87.3%和 90 .6 % ,痊愈率为 5 5 .6 %和 6 0 .9% ,细菌清除率为 84.7%和 89.7%。两药不良反应均轻微且呈一过性 ,发生率为 7.0 %和 4.3% ,主要为皮疹等。两组比较 ,上述差异均无显著性 (P>0 .0 5 )。本研究提示 ,头孢匹胺每日 2～ 4g,疗程 7～ 14d治疗常见细菌性感染的疗效和安全性与头孢哌酮相仿。更多还原

【Abstract】 To evaluate the efficacy and safety of cefpiramide in the treatment of bacterial infections, a randomized controlled study of cefpiramide vs. cefoperazone was carried out. One hundred twenty seven cases with lower respiratory tract or urinary tract infections were enrolled, 63 cases in cefpiramide group, 64 in cefoperazone group. Two or four grams of the two drugs were administered per day each for 7~14 days. The effective rates were 87.3% and 90.6%; the cure rates were 55.6% and 60.9%; the bacteria clearance rates were 84.7% and 89.7%, respectively. The adverse reactions of the two drugs, mainly skin rashes, were mild and transient, the incidences were 7.0% and 4.3% respectively. The differences between the two groups were all not statistical significant ( P >0.05). We can conclude from this study that the efficacy and safety of cefpiramide 2~4g per day for 7~14 days were comparable with those of cefoperazone in the treatment of common bacterial infections.更多还原