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肾癌根治术对病人血清转化生长因子-β1的影响

The Importance of Serum Transforming Growth Factor β-1 Level in Patients with Renal Cell Carcinoma

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【作者】 郭宏骞孙则禹薛兆英辛殿旗张志文

【Author】 GUO Hong qian 1,SUN Ze yu 1,XUE Zao ying 2,et al. (1.Department of Urology,Nanjing Drum Tower Hospital 210008;2.Institute of Urology,Beijing Medical University,Beijing 100034)

【机构】 南京大学附属鼓楼医院泌尿外科!江苏南京210008北京医科大学泌尿外科研究所!北京200034

【摘要】 目的 :探讨血清转化生长因子 β1 (TGF β1 )肾细胞癌侵袭性的作用。方法 :应用酶联免疫吸附试验 (ELISA)方法检测 17例正常人血清TGF β1 和 17例肾细胞癌病人根治术前后TGF β1 浓度。结果 :所有肾细胞癌根治术前病人血清TGF β1 浓度明显高于正常对照组 (P <0 .0 1) ,根治术后血清TGF β1 浓度明显下降 (P <0 .0 1)。结论 :血清TGF β1 浓度可能成为一种判断肾细胞癌预后的瘤标

【Abstract】 Objective:To detect the role of transforming growth factor β 1(TGF β 1)on aggressiveness of renal carcinoma cell.Methods:Serum TGF β 1 was measured by means of enzymelinked immunsorbent assay(ELISA) in 17 cases of renal cell carcinoma(RCC) before and after radical nephrectomy.17 cases of normal subjects were employed as healthy controls.Results:In all case of RCC the levels of TGF β 1 were significant higher than those of the healthy controls( P <0.01).After the operation,serum TGF β 1 was dramatically decreased(P<0.01).Conclusions:Serum TGF β 1 is a possible tumorprognostic marker in RCC.

  • 【文献出处】 镇江医学院学报 ,JOURNAL OF ZHENJIANG MEDICAL COLLEGE , 编辑部邮箱 ,2000年03期
  • 【分类号】R737.11
  • 【下载频次】26
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