【摘要】 目的　探讨冠状动脉内重组链激酶 (r SK)溶栓治疗老年急性心肌梗死 (AMI)患者合并高血压的有效性及安全性。方法　 99例AMI患者年龄均 >70岁 ,平均 (76 8± 5 5 )岁。其中低体重者 49例 (4 9 5 % ) ,溶栓前血压≥ 16 0 10 0mmHg(1mmHg=0 133kPa)者 5 9例 (5 9 6 % )。均接受冠状动脉内r SK溶栓治疗 :2～ 3min内冠状动脉内注入r SK 5万U ,继续以 5 0 0 0U min输入 90min ,总剂量为5 0万U ,遂行冠状动脉造影判断TIMI血流分级。结果　 90min冠状动脉开通率为 71 2 % ,其中TIMI3级达 47 9% ,TIMI 2级 31 1%。无一例颅内出血并发症。结论　本研究提示冠状动脉内r SK溶栓治疗老年AMI患者合并高血压安全、有效。更多还原

【Abstract】 Objective The study was designed to evaluate the safety and efficacy of intracoronary recombinant streptokinase (r SK) in the treatment of acute myocardial infaction (AMI) with risk of intracranial hemorrhage (ICH) Methods 99 patients with AMI were enrolled All the cases were over 70 years old, the body weight of 49 cases (49 5%) were less than 70 kg, 59 cases (59 6%) had hypertention more than 160/100 mm?Hg The r SK was administered by an introcoronary bolus of 5?000 U followered by infusion of 50?000 U over 90 min The primary endpoint was pentency grade (TIMI flow) of the infact related artery (IRA) by coronary angiography (CAG) at 90 min after initiation of treatment Results Coronary reperfusion rate was 71 2% by the 90 th minute CAG TIMI flow 3 was in 47 90%, TIMI 2 in 31 1% No bleeding incidence occurred Conclusion It is suggusted that intracoronary r SK is an effective and safe method for AMI with risk of ICH更多还原