【摘要】 目的 :研究去卵巢大鼠在雌激素缺乏的情况下股骨远端松质骨微结构的变化 .方法 :以三月龄SD大鼠去卵巢造成骨质疏松模型 ,利用扫描电镜对大鼠股骨远端干骺端骨小梁的形态结构进行观察 ,以了解雌激素缺乏时骨小梁的变化 .结果 :雌激素缺乏造成了大鼠骨小梁数目明显减少、骨小梁变细、微损伤增多 .结论 :雌激素缺乏的大鼠股骨远端骨量明显减少、微结构出现了使骨骼力学性能降低的变化 ,导致骨折的危险性加大 .更多还原

【Abstract】 The effect of lacking of estrogen on cancellous mic rostructure of dista l femur was investigated in 3 months old ovariectomized rats(OVX) compared with sham-operated rats(SHAM) by scanning electron microscope. The results showed tha t the bone mass decreased,trabecular lessened and microdamage incresed signific antly in group of OVX than in SHAM,which can reduced mechanical properties of the bone and increased the risk of fracture.更多还原