【摘要】 本实验旨在研究永久性甲状旁腺功能低下不用免疫抑制剂的甲状旁腺同种异体移植。方法　将实验受体鼠分成四组 ,每组 7只 ,两组裸细胞植入肾包囊 ,两组微囊化植入胸锁乳突肌。其中各一组加Caspase抑制剂。移植后隔两周测血钙及甲状旁腺素 (PTH)。结果　裸细胞组 8周内血钙及PTH均降至移植前水平 ,而微囊化组在 12周后仍保持较高水平。结论　不用免疫抑制剂情况下 ,微囊化甲状旁腺移植可保证移植甲状旁腺组织长期存活并有功能 ,可进一步用于临床更多还原

【Abstract】 Objective Treating long-term hypoparathy roidism demand transplantation of parathyroid.This experiment aim at studying allotransplantation of parathyroid tissue without immunosuppression.Methods The receptice rats were divided into four groups,7 in one group.Two graups were naked cells,and were transplanted into renal capsule;while two groups were microencapsulated and were trans planted into sternocleidomastoid muscle.The caspase inhibitor was added in one naked cell group and one microencapsulated group.After transplantation,serum calcium and PTH-N were measured enery 2 weeks.Results The serum calcium and PTH concentration of the groups of naked cells had decreased almost to pretransplant levels.By contrast that of the other groups were significantly higher even afrer 12 weeks.Conclusions Without immunosuppressive drugs,transplants of microencapsulated parathyroid can enable long-term survival and function of allotrnsplanted parathyroid,and this will be used in clinical applications. [更多还原