【摘要】 应用形态计量学方法和化学染色法 ,分别对 6个品系小鼠定量感染曼氏血吸虫后 7.5 wk的肝脏石蜡切片中虫卵肉芽肿面积和肝脏胶原纤维含量进行了定量观察。结果表明 ,感染鼠肝脏虫卵肉芽肿面积在不同种系小鼠间显示出一定差别 ,肝脏胶原含量较对照组均有明显增加。经相关分析 ,不同种系感染鼠肝脏虫卵肉芽肿面积与肝脏胶原含量间不存在相关关系。鉴于虫卵肉芽肿形成与肝纤维化过程在时相上的差别 ,提示两者受不同的免疫病理机制决定更多还原

【Abstract】 In formalin fixed paraffin embedded sections, hepatic egg granulomas and collagen contents from 6 strains of mice infected with Schistosoma mansoni for 7.5 weeks were quantitatively detected by morphometric and chemical stainning methods respectively. The results showed that there were some differences in different strains of mice on both the size of granulomas and the collagen contents. Correlation analysis on the size of granulomas and the collagen contents showed no correlative relationship between them. It was suggested that the lesion of egg granuloma formation and the hepatic fibrosis in schistosomiasis were determined by different immunopathologic mechanismes.更多还原