【摘要】 探讨人脐带组织作为羟基磷灰石（ＨＡ）义眼座置入体的包裹材料的可行性和临床效果。方法对１０只兔行眼球摘除术后将以人脐带包裹的ＨＡ义眼座置入其眶内，于置入术后１，２周及１，２，３，６，８，１０，１２，１４个月将眼座取出，作扫描电子显微镜观察。另对１５例（１５眼）无眼球的患者作脐带包裹ＨＡ义眼座置入术，观察其临床效果。结果动物实验显示脐带与ＨＡ眼座及眶内组织粘连紧密，随着时间推移，越来越浓密的纤维血管组织长入眼座的内联孔洞中。临床应用１５例（１５眼），追踪观察８～１２个月（平均１０个月），１２例结膜愈合良好，眼座活动正常。３例出现结膜裂隙，经行结膜修补或更换眼座后愈合，最终均安装了义眼，活动良好。结论　人脐带可以作为ＨＡ眼座置入体的包裹材料置入眶窝内。更多还原

【Abstract】 Objective Hydroxyapatite (HA) sphere is admitted to be the best orbital implant today, but it can cause some complications, such as conjunctival erosion and implant exposure. The causes of these complications include HA’s mechanical and chemical stimulation to the conjunctiva. In order to protect conjunctiva against HA’s invasion, most authors suggest wrapping the HA sphere with some material. The wrapping materials usually are autogenous or heterogeneous sclera or fascia. These materials are either unavailable or unaccepted by patients. This study was made on human umbilical cord tissue as the wrapping material of HA sphere. Method Hydroxyapatite spheres enveloped in human umbilical cord tissue were inserted in ten rabbits’ orbits. At 1, 2 weeks and 1, 2, 3, 6, 8, 10, 12 and 14 months after implantation, the conjunctival sac was examined. Then the HA sphere was removed and examined with a scanning electron microscope. Fifteen patients received HA orbital implants enveloped in human umbilical cord from September 1996 To December 1997. The pre-and post-operative photographs.of the sockets, the implant motility were analysed. Results The animal experiment showed that the umbilical cord was tightly adherent to the HA sphere and orbital tissue. The fibro-vascular tissue gradually invaded the interconnecting pores of the sphere after implantation. None of the 15 patients had orbital infection or implant extrusion during an average follow-up of 10 months (range of 8-12 months). Three patients had conjunctival erosion, which was well treated. All patients have cosmetically satisfactory motility of the prosthesis. Conclusion Human umbilical cord tissue can be used as wrapping material of hydroxyapatite orbital implant.更多还原