【摘要】 目的　研究头皮局部性激素受体水平在男性型秃发发生机理中的作用。方法　自1996～ 1998年应用荧光素类固醇激素结合法 ,对 8例男性型秃发患者的正常生发区和秃发区的雌、雄激素受体进行对比检测 ,同时对自体头发移植术后供、受区头皮再行检测。结果　秃发区头皮外毛根鞘、皮脂腺及毛乳头中的雄激素受体阳性细胞百分率明显高于正常生发区 (P <0 0 1) ,秃发区外毛根鞘中雌激素受体阳性细胞百分率明显高于正常生发区 ,而毛乳头中则低于正常生发区 (P <0 0 1)。结论　头皮某些敏感部位 (如额、顶部 ) ,其性激素受体含量的变化 ,是导致男性型秃发发生的原因。更多还原

【Abstract】 Objective\ To study the role of sex hormone receptor capacity of the scalp in male pattern baldness(MPB).Methods\ Estrogen receptor(ER) and androgen receptor(AR) assays were performed using fluorescent steroid hormone conjugate technique (FSHCT) in hairness and bald scalp in 8 patients with MPB.Changes of ER and AR capacity in recipient and donor sites of hair transplantation in MPB scalps were examined.Results\ The percentage of AR staining cells in the outer root sheath,sebaceous gland and bulb papilla of the lesional scalps was significantly higher than that of hairness scalps (P<0 01) .The percentage of ER positive cells in the outer root sheath of lesional scalps increased significantly (P<0 01) .Conclusion\ Changes of contents of sex hormone receptors(SHR) in some sensitive area of the scalp induce MPB.更多还原