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电损毁延髓最后区对犬消化间期移行性复合运动的作用

Effect of electrical lesion of the area postrema on gastrointestinal interdigestive migrating motor complex in conscious dogs

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【作者】 王礼建周吕田瑞

【Author】 WANG Lijian, ZHOU Lü, TIAN Rui. Department of Physiology, Institute of Basic Medical Science, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China

【机构】 中国医学科学院基础医学研究所中国协和医科大学基础医学院生理研究室

【摘要】 目的 探讨延髓最后区对胃肠消化间期移行性复合运动 (MMC)的影响。方法 应用 8只犬进行慢性实验 ,在胃窦和十二指肠浆膜埋植应力传感器记录胃窦和十二指肠消化间期复合运动。在一侧股静脉内置慢性静脉插管供注射外源性胃动素。用放射免疫法 (RIA)测定血浆胃动素含量。观察 :(1)消化间期正常MMC活动和血浆胃动素浓度变化 ;(2 )电损毁延髓最后区对MMC活动和血浆胃动素水平的影响 ;(3)电损毁延髓最后区对外源性胃动素启动MMCⅢ相收缩作用的影响。结果 (1)正常犬消化间期出现典型的Ⅰ、Ⅱ、Ⅲ、Ⅳ相MMC。MMCⅢ相与血浆胃动素释放高峰同步发生。(2 )电损毁延髓最后区后 ,胃窦和十二指肠MMC的收缩运动明显抑制 ,MMCⅠ相延长 ,Ⅱ、Ⅲ相明显缩短 ,失去了损毁前MMC周期性、时相性和移行性的特点 ,血浆胃动素浓度明显降低 ,外源性静脉注射胃动素不能启动MMCⅢ相收缩。结论 延髓最后区对消化间期MMC的周期发生和移行有重要的调控作用 ,其作用途径与胃动素介导有关。

【Abstract】 Objective To investigate the effect of area postrema (AP) of medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC). Methods Interdigestive MMC activity of antrum and duodenum was recorded by strain gauge implanted on the serosa in 8 conscious dogs. Cannula was intubated in the femoral vein for motilin injection. Plasma motilin concentration was measured by RIA. We observed (1) normal interdigestive MMC activity and fluctuation of plasma motilin concentration; (2) the effect of electrically destroying AP on MMC activity and plasma motilin level and (3) whether or not intravenous injection of motilin could induce phase Ⅲ contractions after AP was destroyed. Results (1) Typical interdigestive MMC with phases Ⅰ, Ⅱ, Ⅲ and Ⅳ was recorded in normal dogs. Phase Ⅲ was concurrent with the peak of plasma motilin level. (2) In dogs electrically destroyed AP with antroduodenal interdigestive MMC contractions were suppressed; cyclic, phasic and migratory pattern of MMC was disrupted. Plasma motilin concentration was decreased. Intravenous injection of motilin could not induce phase III contractions. Conclusion Area postrema plays an important role, which is mediated by motilin, on the regulation of interdigestive MMC.

【关键词】 延髓消化生理学胃动素
【Key words】 Medulla oblongataDigestive, physiologyMoti?
【基金】 国家九五攀登计划项目! (95 预 19 2 2 2 ) ;国家自然科学基金!资助项目 (39770 2 85 )
  • 【文献出处】 中华医学杂志 ,National Medical Journal of China , 编辑部邮箱 ,2000年10期
  • 【被引频次】13
  • 【下载频次】63
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