【摘要】 目的　观察乙型肝炎疫苗接种 10年后远期效果 ,为确定复种时间提供依据。方法　按随机、双盲、安慰剂对照严格设计 ,对乙型肝炎疫苗接种 11年后效果及免疫记忆进行观察。结果　 11年疫苗免疫原性和保护率仍好 ,对HBV感染保护率 73 5 % ,但 9～ 11年观察时段HBV感染率疫苗组和安慰剂组差异已无显著性 (7 89%与 13 2 5 % ) ;11年有免疫记忆存在 ,但较 10年内明显减弱。结论接种后 11年疫苗效果已开始下降 ,应继续追踪观察 ,以期得出确切结论。更多还原

【Abstract】 Objective To evaluate the long term efficacy of hepatitis B vaccine 10 years after primary immunization to provide scientific basis for the time of revaccination. Methods The study was strictly designed with randomization, double blinding, and placebo controlled method to observe the efficacy and immune memory 11 years following hepatitis B vaccination. Results Immunogenicity and protective rate of vaccine were still kept well 11 years after immunization with a protective rate against HBV infection of 73 5%. But, there was no significant difference in HBV infection rates between vaccine group and placebo controlled group (7 89% vs. 13 25%, P> 0 1) nine to 11 years following immunization. There still existed immune memeory 11 years after immunization, but it was significantly weaker than that within the first 10 years after immunization. Conclusion The efficacy of the vaccine had begun to drop 11years after immunization, which should be followed up further to reach a clear conclusion.更多还原