【摘要】 目的　研究我国北方胰岛素依赖型糖尿病人与HLADR,DQ的关联。方法　对华北地区53名胰岛素依赖型糖尿病(IDDM)儿童进行了HLADRB1、DQA1、DQB1分型,同185名进行了同样分型的华北正常对照组人群进行关联分析。结果　发现DRB10301/DRB104杂合子个体具有最高的风险(RR=5113)。进一步分析DQ分子,将DQα链第52位为精氨酸和DQβ链第57位为非天冬氨酸分别命名为S(易感)因子,发现当个体拥有的易感基因组合S≥3时具有很大的风险(RR=29.89),反之,当P(保护因子)≥2时即显保护作用。但考虑到DR3/DR4杂合子的风险较高,DR分子与IDDM易感性的关联仍不能忽视。结论　DR3/DR4杂合子可以作为预测和预报IDDM风险的首选指标提示发病明显提早。DQADQB的S因子组合≥3可作为预测和预报IDDM的次级指标。某些DR分子与IDDM易感性的关系有可能通过DR4亚型分析得到进一步明确。更多还原

【Abstract】 Objective To study the association between insulin dependent diabetes mellitus (IDDM) and HLA DR, DQ molecules. Methods Fifty three IDDM cases and 185 controls in northern China were HLA class Ⅱ DNA typed for DRB1, DQA1 and DQB1 analysis. Results DRB1*0301/DRB1*04 heterozygous was in the highest risk with the RR value of 51.13. By making the DQ analysis of Arg in the position 52 of DQ α chain as a susceptible factor (named as S, the opposite is P) and the non Asp in position 57 of DQ β chain as an another susceptible factor (S and P). The highest risk was found when an individual has the factor combination S≥3 (RR=29 89), and the protective factors were appeared when P≥2. However, the factors from DR molecule still could not be ignored since the RR value of DR3/DR4 heterozygous was 51.13. Conclusions The DR3/4 heterozygous can be the first marker for forecasting the IDDM susceptibility, and the 3S factor can be the second way for IDDM forecasting and prevention. In addition to DQ molecules, the susceptible factors from DR alleles could be further clarified by DR4 subtyping.更多还原