【摘要】 目的　探讨妊高征患者白细胞介素 6 (IL- 6 )与免疫球蛋白 (Ig)的相关性。　方法　用放射免疫法检测妊高征患者 5 0例 (妊高征组 ,其中中度 2 4例 ,重度 2 6例 )及正常足月妊娠 30例 (正常足月妊娠组 )的母血、脐血中的 IL- 6含量 ,采用速率散射比浊法检测同样标本中的 Ig G、Ig M、Ig A的含量。　结果　重度妊高征患者母血中 IL- 6的含量为 (16 7.2 0± 72 .5 2 ) ng/ L,脐血中 IL- 6含量为 (133.2 0±85 .5 5 ) ng/ L,均较正常孕妇显著增高 ,差异显著 (P<0 .0 1,P<0 .0 1) ,中度妊高征患者母血中 IL- 6的含量为 (12 4.40± 86 .37) ng/ L,脐血中 IL- 6含量为 (97.33± 74.16 ) ng/ L,均较正常孕妇显著增高 ,差异显著 (P<0 .0 5 ,P<0 .0 5 )。中度妊高征母血 Ig G含量为 (7.0 1± 2 .0 9) g/ L,而重度妊高征母血 Ig G含量为 (7.43± 1.6 6 ) g/ L,均显著低于正常妊娠组 (P<0 .0 1,P<0 .0 1) ,与母血 IL- 6含量呈显著负相关关系 (r=- 0 .779,P<0 .0 1;r=- 0 .80 6 ,P<0 .0 1)。　结论　 IL- 6与 Ig G协同作用 ,共同参与了妊高征的免疫损伤过程 ,提示 :如能使母血中 IL- 6降低 ,Ig G升高 ,有可能防治妊高征。更多还原

【Abstract】 Objective To study the relationship between the level of interleukin 6 (IL 6) and immunoglobulin (Ig) and pregnancy induced hypertension (PIH). Methods The subjects were divided into PIH group ( n =50, 24 moderate PIH, 26 severe PIH) and normal pregnant group ( n= 30). The levels of IL 6 in maternal and umbilical serum were detected by radioimmunoassay. The levels of IgG,IgA,IgM in both serums were detected by nephelometry. Results (1)The levels of IL 6 in maternal serum [(167±72.52)ng/L] and umbilical serum[(133.20±85.55)ng/L] in severe PIH were significantly higher than that in the normal pregnant group ( P<0.01;P <0.01),respectively. The levels of IL 6 in maternal serum [(124.40±86.37)ng/L] and umbilical serum [(97.33±74.16)ng/L] of moderate PIH were significantly higher than that of normal pregnant group ( P< 0.05 ;P <0.05), respectively. (2) The levels of IgG in maternal serum of severe [(7.43±1.66)g/L] and moderate [(7.01±2.09)g/L] PIH were significantly lower than that of the normal pregnancy ( P<0.01;P <0.01), respectively. (3) A negative correlation was shown between the level of IL 6 and that of IgG in maternal serum. Conclusion IL 6 and IgG may produce in the immuno damaged process in PIH cooperately.更多还原