【摘要】 目的 探讨美托洛尔对慢性充血性心衰患者的心功能和运动耐量的影响.方法 慢性充血性心衰患者42例,分为缺血性心肌病和扩张型心肌病两组,在常规抗心衰治疗基础上,加用小剂量美托洛尔,治疗前后监测左室射血分数,舒张早期与晚期充盈峰速度及二者比率,心功能分级和运动耐量变化.结果 扩张型心肌病组各项指标改善优于缺血性心肌病组.结论 美托洛尔能抑制慢性充血性心衰患者过度兴奋的交感神经,减少其对心肌的不良作用,提高心功能和运动耐量,对以β₁受体下调为主的扩张型心肌病更为适用.更多还原

【Abstract】 [Abstract] Objective To study the effect of Metoprolol on heart function and movement endurance in patients with chronic congestive heart failure.Methods Forty-two patients with the diagnosis of chronic congestive heart failure were allocated to two subgroups:Subgroup one was the patients with dilated cardiomyopathy;Subgroup two was the Patients with ischemic cardiomyopathy. To study the effect of Metoprolol treatment on LVEF,Ei/Ai, the degrees of heart function and movenment endurance were obtained, before and after treatment with Metoprolol. Results The data from patients with dilated cardiomyopathy were better than those with ischemic cardiomyopathy .Conclusion Metoprolol can inhibit ultra excited sympathicus in patients with chronic congestive heart failure and decrease the toxicity effect to heart and improve heart function and movement endurance.It could be better used in patient with dilated cardiomyopathy because of the decreasing of β1-receptor.更多还原