【摘要】 目的　总结分析脑脓肿病原菌的长期细菌培养结果及其发展变化特点。方法　回顾性地观察四十八年间脑脓肿病原菌的培养结果 ,并结合脑脓肿的来源、类型及不同时期进行分组比较。结果　脑脓肿发病率呈下降趋势。本组 5 98例脑脓肿的细菌培养阳性率为 6 3 2 % ,近 10年细菌培养阳性率已降致 47 9%。单一细菌感染占 6 8 3% ,混合感染占 31 8%。最常见的致病菌是 :链球菌(32 0 % )、葡萄球菌 (2 9 1% )、变形杆菌 (2 8 0 % )。厌氧菌培养阳性率为 2 0 0 % ,常见的厌氧菌是 :厌氧性链球菌、脆弱拟杆菌、黑色素拟杆菌。结论　近年来脑脓肿细菌培养的阳性率也显著下降 ,直接播散型脑脓肿比例逐渐减少 ,而隐源性脑脓肿的比例逐渐增高 ,病原菌培养时链球菌、葡萄球菌的阳性率有逐渐上升的趋势 ,厌氧菌感染和多种细菌混合感染应引起重视更多还原

【Abstract】 Objective To analyze the results of pathogen culture and explore development characteristics of brain abscess.Methods Retrospectively observe the results of pathogen culture of brain abscess during 48 years, and perform comparison between different groups on the basis of abscess resource, type and stage.Results The incidence of brain abscess tends to decrease. The positive rates of bacteria culture in these 598 cases was 63 2%, but it has decreased to 47 9% during the recent ten years. The rates of monoinfection and polyinfection was 68 3% and 31 8% respectively. The most common pathogens included of Streptococcus (32 0%), Staphylococcus (29 1%) and Bacillus proteus (28 0%). The positive rate of anaerobia culture was 20 0%. Streptococcus anaerobius, Bacaeroides fragilis and Bacaeroides melaninogenicus were common anaerobia. Conclusions Recently the positive rates of bacteria culture of brain abscess decrease significantly. The incidence of brain abscess, which is disseminated directly, tends to decrease. But the incidence of cryptogenic infection increases gradually. Streptococcus and Staphylococcus increase in culture. The infections of anaerobia and mixed infection should be paid more attention to.更多还原