【摘要】 目的　探讨兔脑血管动脉瘤的病因及发病机制。方法　将 2 8只兔随机分为 4组 ,用静脉注射马血清 (A组 )、颈局部注射马血清 (B组 )、颈动脉部分结扎 (C组 )和颈局部注射去甲肾上腺素 (D组 ) 4种方法 ,建立兔动脉瘤模型。用脑血管造影和组织病理学方法观察动脉瘤。结果　 2 8只鼠共发现 10个动脉瘤 ,其中A组 2只 2个 ,B组 3只 4个 ,C组 3只 3个 ,D组 1只 1个。结论　变态反应、机械性缺血和持续性血管痉挛等因素是产生动脉瘤的直接原因。更多还原

【Abstract】 Objective To invectigate the etiology and pathogenesis of intracranial aneurysm. Methods Four experimental animal models of intracranial aneurysm were established with normal horse serum injected into veins or the neck regions, or into both common carotid arteries which were narrowed, by using silk ligature or noradrenalin injection into the neck regions. Results Ten intracranial aneurysms were found in the experimental animal model.Conclusion The immunological response,arteryischemia and continuous vasospasm may be considered the direct pathogenic factors of the intracranial aneurysm.更多还原