【摘要】 目的　研究伤口愈合过程中 ,粘附分子整合素家族在介导细胞与细胞外基质间的主要作用。　方法　运用原位杂交技术对 12例中厚取皮区创面成纤维细胞表面整合素α5、β1亚基mRNA表达进行了检测。　结果　中厚取皮供区整合素α5、β1染色阳性的真皮成纤维细胞密度较正常皮肤显著增高。　结论　上述结果提示创面成纤维细胞整合素α5、β1表达增高可能参与伤口愈合时高产量胶原成纤维细胞亚群的激活更多还原

【Abstract】 Objective To explore the potential role of integrin family in mediating the interaction between cells and extracellular matrix(ECM) during wound healing. Methods In situ hybridization technique was employed in the determination of the expression of the mRNA of the subunits of integrinα 5,β 1 on the surface of fibroblasts in the donor sites of partial thickness skin of 12 burned patients. Results Evidently more integrin α 5,β 1 positive staining fibroblasts were found in the donor site than in normal skin (P<0.05). Conclusion The results suggested that increased expression of integrin α 5,β 1 in the wound might be involved in the activation of collagen-overproductive subpopulation of fibroblasts.更多还原