【摘要】 目的　探讨原位肝移植治疗急性重型乙型肝炎的效果。方法　在体外静脉转流下对 7例急性重型乙型肝炎患者行原位肝移植 ,5例患者伴有不同程度的肝性脑病 ,1例合并急性肾功能衰竭 ,1例合并上消化道大出血。术后存活者均服用拉咪呋啶预防乙型肝炎的复发。结果　术后 5例存活 ,2例死亡。术前伴有肾功能衰竭的 1例 ,术后 3d死于多器官功能衰竭 ;另 1例术后 44d死于重型肝炎 (复发 )。 5例存活者观察期内 (2～ 6个月 )未见乙型肝炎复发。结论　原位肝移植术是治疗急性重型乙型肝炎的有效方法之一更多还原

【Abstract】 Objectives To investigate the therapeutic effects of orthotopic liver transplantation in the treatment of fulminant hepatitis B and the efficiency of lamivudine on recurrence of hepatitis B. Methods Seven patients with fulminant hepatitis B received orthotopic liver transplantation under veno venous bypass. All patients had serious jaundice, ascites and hemorrhagic tendency, and of whom 5 were associated with encephalopathy, 1 with acute renal failure, and 1 with gastrohemorrhage. Results Five patients survived for 2 to 6 months after transplantation, 2 died of multi organ failure or recurrence of fulminant hepatitis B . No recurrence of hepatitis B was found in the 5 survival patients taking lamivudine. Conclusions Orthotopic liver transplantation is an effective therapy for fulminant hepatitis B, and lamivudine may prevent recurrence of hepatitis B after transplantation.更多还原