【摘要】 目的　观察地氟醚对老年病人血液动力学的影响。方法　择期老年手术病人 30例 ,ASAⅠ～Ⅱ级。硫喷妥钠、琥珀胆碱、芬太尼诱导插管后 ,经口插入经食管多普勒心输出量测定仪。观察不同MAC地氟醚对老年病人的CO、PV、HR、FTC、CVP、CI、MAP、SVR的影响。结果　与吸入前相比 ,MAP、SVR在 1 0MAC、1 5MAC及 2 0MAC时显著下降 (P <0 0 5或 0 0 1) ,HR、FTC在 0 5MAC时无明显变化 (P >0 0 5 ) ,在 1 0MAC、1 5MAC及 2 0MAC时显著增加 (P <0 0 5或 0 0 1) ,CVP在 0 5MAC、1 0MAC、1 5MAC及 2 0MAC时明显升高 (P <0 0 5或 0 0 1) ,CO、PV、CI在 0 5MAC、1 0MAC、1 5MAC及 2 0MAC时均无显著性差异 (P >0 0 5 )。结论　地氟醚对心血管系统影响较小 ,由于老年病人代偿能力下降 ,在 1 0MAC以上浓度时 ,应注意维持血液动力学的稳定。更多还原

【Abstract】 Objective To investigate the effects of desflurane on hemodynamics in aged patients.Methods Thirty ASA gradeⅠ Ⅱaged patients,scheduled for elective surgery,were studied. Anesthesia was induced with intravenous thiopentol,succinylcholine and fentanyl.After intubation coesophageal Doppler monitor was performed to measure CO,PV,HR,FTC,CVP,CI,MAP and SVR following inhalation of desflurane at 0 5MAC,1 0MAC,1 5MAC and 2 0MAC respectively.Results Compared with those before inhalation desflurane,MAP and SVR decreased more significantly at 1 0MAC,1 5MAC and 2 0MAC(P<0 05 or 0 01), no significant changes occurred in HR and FTC at 0 5MAC(P>0 05),HR and FTC increased significantly at 1.0MAC,1.5MAC and 2.0MAC(P<0 05 or 0 01),CVP increased significantly at 0.5MAC,1.0MAC,1.5MAC and 2.0MAC(P<0 05 or 0 01),no significant changes occurred in CO,PV and CI at any MAC of desflurane. Conclusion The influence of desflurane on cardiovascular system is minor in aged patient but due to the decrease of compensation ,it is necessary to maintain the stablilization of hemodynamics with the concentration of desflurane being more than 1.0 MAC.更多还原