【摘要】 目的　了解麻醉与手术对肾小球和肾小管功能的影响。方法　病人分为 4组 :1、全身麻醉 +较大手术组 (G +B) ;2、全身麻醉 +较小手术组 (G +S) ;3、硬膜外阻滞 +较大手术组 (E +B) ;4、硬膜外阻滞 +较小手术组 (E +S)。每组 10例。检测术前、术中 1h和术后 2 4h尿中 β2 微球蛋白 (β2 MG)、白蛋白 (Alb)和免疫球蛋白G(IgG)浓度。结果　在不同麻醉方法下行较小手术时 ,术中及术后尿中 β2 MG、Alb、IgG无显著性变化 (P >0 0 5 ) ,而较大手术两组病人的术中及术后尿中β2 MG、Alb、IgG浓度明显升高 (P <0 0 5 ) ,个别病人呈尿蛋白阳性。结论　围术期肾小球和肾小管功能与麻醉的关系较小 ,与手术刺激的程度关系较大更多还原

【Abstract】 Objective To investigate the effects of anesthesia and operation on glomerular and renal tubular function Methods Forty patients without renal disease were assigned to 4 groups: general anesthesia + minor operation; general anesthesia +major operation; epidural block + minor operation and epidural block + major operation The concentration of β₂-microglobulin（β₂-MG）、albumin（Alb）and immunoglobulin G（IgG）in urine were measured before operation ,1h following operation and 24h after operationResults In the groups of major operation, the concentrations of β₂-MG, Alb and IgG in urine increased significantly during and after operation（P<005）, but without significant changes in the groups of minor operation（P>005）Conclusions The influences on renal glomerular and tubular function during perioperation are related to the degree of operative stimulation, but do not to the anesthesia更多还原