【摘要】 目的　探讨精神分裂症和抑郁症患者事件相关电位 (ERPs)P3 0 0 的P3 波异常的意义。方法　对 2 1例精神分裂症、15例抑郁症患者在未服药和停药半年后的发病期及 2年缓解期后采用视觉图像辨认作业引出中央点P3 0 0 ,并与 2 4名正常对照者进行比较。结果　两病例组在发病期P3 潜伏期 [精神分裂症组 (431± 42 )ms,抑郁症组 (40 5± 32 )ms]延长、波幅 [精神分裂症组 (4 7± 2 0 ) μV ,抑郁症组 (5 3± 2 7) μV]下降 ,与对照组 [(36 7± 13)ms、(9 3± 3 1) μV]间的差异有显著性 ;缓解期复查仅精神分裂症组P3 潜伏期 [(410± 30 )ms]及波幅 [(7 1± 3 3) μV]异常较明显 ,抑郁症组潜伏期[(374± 9)ms,波幅为 (8 1± 4 1) μV]与对照组间的差异无显著性。结论　精神分裂症P3 波异常具一定跨状态稳定性 ,其中潜伏期的延长更为稳定 ;而在抑郁症则与临床状态有关。更多还原

【Abstract】 Objective To explored the meanings of P 3 abnormality in schizophrenia and depression. Methods The P 300 Event related potentials(ERPs) of Cz during a visual discriminative task were recorded in 21 schizophrenic and 15 major depressive patients in both their episode of medication free or drug naive and clinical remission after two year The P 300 were also made in 24 age and education matched normal control subjects Results Mean latencies and amplitudes of the P 3 in schizophrenic patients in both episode (431±42) ms、(4 7±2 0)μV and remission (410±30) ms、(7 1±3 3)μV significantly differed from those of normal controls (367±13) ms、(9 3±3 1)μV; in depressed patients, the P 3 amplitude reduction and latency prolongation were only in episode (405±32) ms、(5 3±2 7)μV, but became normal (374±9) ms、(8 1±4 1)μV after two years treatment Conclusions It is suggested that the P 3 amplitude reduction and latency prolongation, which indicate an impairment of visual cognitive information processing in this study, are independent of clinical state in schizophrenia, but those abnormalities in depression are state related更多还原