【摘要】 目的探讨胃癌多药耐药（ＭＤＲ）表达与预后，凋亡指数（ＡＩ）与预后及ＭＤＲ与ＡＩ表达之间的关系。［方法］应用免疫 组化的方法及ＴＵＮＥＬ法，结合１９８７年～１９９１年的完整胃癌病例进行１０年随访，对胃癌ＭＤＲ的主要指标Ｐ－ｇｐ、ＧＳＴ－π、ＤＮＡ ＴＯＰＯ Ⅱ及细胞ＡＩ进行检测。［结果］Ｐ－ｇｐ表达与临床分期有关（Ｐ＜０．０５），正常组织表达Ｐ－ｇｐ高者生存期长（Ｐ＜０．０５）。ＧＳＴ－π表达强度 与预后有关（Ｐ＜０．０５）。ＴＯＰＯ Ⅱ表达与分型有关（Ｐ＜０．０５）。凋亡指数表达与临床分期有关（Ｐ＜０．０５）。Ｐ－ｇｐ里表达与ＧＳＴ－π表达 之间相关（Ｐ＜０．０５），ＧＳＴ－π与ＴＯＰＯ Ⅱ表达相关（Ｐ＜０．０５），但多药耐药表达与细胞ＡＩ之间无关（Ｐ＞０．０５）。［结论］ＭＤＲ与ＡＩ都 属细胞正常基因组表达的一部分，ＭＤＲ主要功能是细胞防御，其表达产物之间有相关性。细胞凋亡功能为细胞自稳，也由基因控 制，但与ＭＤＲ调控基因无相关，不同生存年段其ＭＤＲ与ＡＩ表达未见有明显统计差异（Ｐ＞０．０５）。提示单因素分析ＭＤＲ／ＡＩ与预 后尚不够全面。更多还原

【Abstract】 Purpose] To study the clinical significance of expression of MDR and Al in gastric cancer. [Methods] Eighty eases of paraffin embedded gastric cancer tissues were analyzed for the presence of P-gp, GST-π and TOPO Ⅱ, by means of immunohistochemistry method and AI measured by TUNEL method. [Results] The result showed that the higher P-gp expression in noed tissue, the longer the survival. The expression of P-gp related to staging (P<0.05). The positive relationship existed between the strength of GST-π expression and the survial time. The expression of TOPO Ⅱ was associated with tissue differentiation(P<0.05). Apoptosis index related with clinical stage of gastric carcinoma. There was no relationship between MDR and apoptosis (P>0.05) [Conclusion] MDR expression and Al belong to normal cell’s events presented in both normal and tumor tissues. The different expression depends on their biologic behavior and the gene deformities. Single variable analysis is not enough to indicate prognosis更多还原