【摘要】 目的　探讨用冷冻异体骨膜作为引导骨组织再生膜的可能性。方法　取兔颅骨顶部骨膜经冷冻处理 ,在 31只日本大耳白兔的下颌骨造成两处骨缺失 ,采取同体对照 ,一处表面覆盖冷冻异体骨膜 ,另一处不覆盖。分别在第 4、8、12、16周处死动物 ,行X线及组织学观察。结果　冷冻异体骨膜不产生排斥反应 ,可在体内维持 8～ 12周 ,具有良好的阻挡纤维组织长入骨创面、分隔不同细胞及引导组织再生的功效。结论　冷冻异体骨膜是一种理想的引导骨组织再生膜更多还原

【Abstract】 Objective Explores the feasibility of guiding bone tissue regeneration by frozen homologous periosteum. Methods Rabbit’s cranial periosteum was taken and refrigerated . In thirty-one white Japanese big ear rabbits,defects of the mandible were created . Defect at one side was covered with the membrane, another side not. The rabbits were sacrificed on four, eight, twelve, sixteen weeks.Specimens were examined by naked eye, X-ray, and histology. Results The frozen homologous periosteummet the requirement of guiding bone tissue regeneration There was no rejection, and could be kept 8 for 12 weeks in the body.It had the favorable efficacy of obstructing the fiber tissue from filling into bone defects and had an efficacy of guiding bone tissue regeneration. Conclusions Frozen homologous periosteum is a perfect guiding bone tissue regeneration membrane.更多还原