【摘要】 目的　回顾性分析Ⅰ、Ⅱ期胃原发非霍奇金淋巴瘤病例 ,探讨手术、放射治疗和化疗在其治疗中的地位。方法　经手术后病理确诊为Ⅰ、Ⅱ期胃原发非霍奇金淋巴瘤 84例 ,其中 43例接受术后放射治疗和化疗 ,2 5例仅接受术后放射治疗和 8例仅接受术后化疗。放射治疗采用6 0 Co或 6、18MVX射线。化疗采用CHOP、COP、COPP、COMP和COBDP方案。生存率采用Kaplan Meier法计算及Logrank检验 ,多因素分析采用Cox回归模型。结果　全组病例 3、5年生存率分别为 82 .1%和 78.6 % ,其中Ⅰ期和Ⅱ期 3、5年生存率分别为 98.0 %和 5 8.8% ,96 .0 %和 5 2 .9% ,P =0 .0 0 3。单因素和多因素分析显示临床分期和放射治疗与否是独立预后因素。结论　手术在Ⅰ、Ⅱ期胃原发非霍奇金淋巴瘤的治疗中占主导地位 ,术后放射治疗能提高患者的生存率 ,而化疗作用不能肯定更多还原

【Abstract】 Objective A retrospective analysis was carried out to evaluate the role of surgery, radiotherapy and chemotherapy for Stage Ⅰ and Ⅱ primary non Hodgkin’s lymphoma (NHL) of the stomach. Methods Eighty four patients with StageⅠ andⅡ primary NHL were initially treated with surgery. Fourty three patients received postoperative radiotherapy plus chemotherapy,25 received postoperative radiotherapy and 8 received postoperative chemotherapy, respectively. Radiotherapy was given with cobalt 60 or 6,18 MV X ray. Chemotherapy regimens included CHOP,COP,COPP,COMP or COBDP. The significance of prognostic variables in the survival was evaluated by univariate analysis and Cox regression model. Results The overall 3 and 5 year survival rates were 82.1% and 78.6%, respectively. The 3 and 5 year survival rates were 98.0% and 96.0% for Stage Ⅰ, 58.8% and 52.9% for Stage Ⅱ(P=0.003). Univariate and multivariate analyses showed that patients with Stage Ⅰand radiotherapy gave better survival. Conclusion Surgery is the management of choice for Stage Ⅰ and Ⅱ primary non Hodgkin’ lymphoma of the stomach. Radiotherapy is able to prolong the survival, but the role of chemotherapy is not conclusive.更多还原