【摘要】 探讨不能手术的食管癌热疗配合放射治疗的效果。方法　回顾性分析 5 0例不能手术的食管癌热疗配合放射治疗的临床资料。 5 0例中男性 43例 ,女性 7例 ;鳞癌 46例 ,腺癌 1例 ,小细胞癌 3例。热疗采用 8MHz深部射频热疗机 ,在放射后 10～ 6 0min内进行加温 ,每次治疗 5 0min ,每周 1～ 2次。放射治疗采用 8MVX射线或6 0 Coγ射线 ,常规分割照射 ,总剂量 6 0～ 70Gy ,6～ 7周者 42例 ,72～ 76Gy ,7～ 8周者 4例 ,5 0Gy以下者 4例 ,治疗效果均以食管钡餐检查为评价手段。采用Kaplan Meier法进行生存率分析、Logrank法检验 ,分析不同的热疗参数对疗效的影响。 结果　热疗次数达 3次以上者 1、2年生存率均高于 3次以下者 ,分别为 42 .5 %、17.5 %及 10 .0 %、0 .0 % (P<0 .0 1) ;热疗有效功率 80 0W以上的 1、2年生存率比 80 0W以下高 ,分别为 46 .9%、18.8%及16 .7%、5 .6 % (P <0 .0 5 )。结论　热疗配合放射治疗食管癌亦应注意有效功率及热疗次数。更多还原

【Abstract】 Objective To evaluate the efficiency of thermo-radiotherapy for unresectable esophageal cancer.Methods A retrospective analysis was performed on 50 patients with unresectable esophageal cancer treated by radiotherapy combined with hyperthermia. Heating was administered 10～60 minutes after completion of radiation,using a 8?MHz radiofrequency unit, 50 minutes per session,once or twice a week. For radiotherapy, 60 Co γ-ray or 8 MV X-ray was delivered with conventional fractionation. Of all the 50 patients, 42 received a total dose of 60 to 70 Gy over 6～7 weeks, 4 received 72 to 76 Gy over 7～8 weeks and the others, less than 50 Gy. Barium esophagography was conducted to determine the effects of thermo-radiotherapy. Kaplan-Meier analysis and Logrank test were used to evaluate survival rates and to study the influence from different thermo-parameters on treatment results.Results The 1-,2-year survival rates were better for patients underwent hyperthermia over 3 sessions than any fewer, 42.5% and 17.5% vs 10.0% and 0.0%,respectively, with a very significant difference (P<0.01). The effective thermo-power was considered as 800 W or higher. The 1-,2-year survival rates were 46.9% and 18.8% in the higher than 800 W group, 16.7% and 5.6% in the less than 800 W group. The former is better (P<0.05).Conclusion In thermo-radiotherapy for esophageal cancer, the thermo-power and number of hyperthermia sessions should be paid due attention.更多还原