【摘要】 目的　探讨妊娠期暴发型肝功能衰竭 (FHFP)的临床 ,生化 ,病原学特点。方法　观察2 1例FHFP临床表现 ,并分析实验室资料 ,13例作肝组织学检查。结果　乙型肝炎病毒感染 7例 ,乙型肝炎病毒、戊型肝炎病毒重叠感染 2例。FHFP血清白蛋白极显著低于妊娠期急性肝炎和慢性肝炎 ,分别为 (2 5 .19± 6 .95 )、(33.17± 3.44 )及 (33.80± 3.78) g/L(均P <0 .0 1)。肝组织学诊断为 ,存活的 6例中 ,急性肝炎 1例 ,慢性肝炎 4例 ,瘀胆型肝炎 1例。死亡 7例中 ,慢性肝炎 4例 ,瘀胆型肝炎 2例 ,产前子痫肝损害 1例。结论　肝炎病毒是FHFP的病因之一。低蛋白血症在FHFP发病中起着重要作用 ;FHFP可能是一种独特的综合征更多还原

【Abstract】 Objective To study the clinical, biochemical and serological profiles of fulminant hepatic failure during pregnancy (FHFP).Methods Clinical and laboratory data were analyzed in 21 patients with FHFP. Hepatic biopsies were undertaken in 13 cases.Results The results of serologic tests showed that 7 cases were infected by hepatitis B alone and other 2 cases were superinfected with hepatitis B and hepatitis E virus. Results of liver function tests showed levels of serum albumin in FHFP patients were significantly lower than those in the patients with chronic hepatitis and acute hepatitis during pregnancy (both P < 0.01 ). Seven died patients were histopathologically diagnosed as chronic hepatitis in 4, cholestatic hepatitis in 2, and pre eclampsia induced liver lesion in 1 respectively. Among 6 surviviors, 1 acute hepatitis, 4 chronic hepatitis and 1 cholestatic hepatitis were found.Conclusion Hepatitis virus is one of etiological factors contributing to FHFP. Severe hypoalbuminemia may play an important role in the pathogenesis of FHFP. FHFP may be defined as an unique syndrome in the infections of hepatitis virus.更多还原