【摘要】 目的 :对伊犁贝母总生物碱 (FPA)、梭砂贝母总生物碱 (FDA)生物活性进行初步比较。方法 :采用小鼠二甲苯耳水肿、SO2 引发小鼠咳嗽、酚红法祛痰实验及细菌体外培养等方法。结果 :伊犁贝母和梭砂贝母的总生物碱以 40 0mg·kg-1,2 0 0mg·kg-1剂量一次性灌胃给药 ,具有明显的抗炎、镇咳、祛痰作用 ,伊犁贝母的作用效果在某些方面略强于梭砂贝母 ;在相同生药量下同样表现出前者强于后者的作用效果。伊犁贝母对流感嗜血杆菌、金黄色葡萄球菌、肺炎球菌等多种细菌有不同程度的抑菌作用 ,梭砂贝母与之相比抑菌作用较弱。结论 :伊犁贝母抗炎、镇咳、祛痰、抑菌作用略强于梭砂贝母。更多还原

【Abstract】 Objective:To compare the physiological activity of Fritillaria pallidiflora alkaloids(FPA)with that of F. delavayi alkaloids(FDA).Method:Xylene induced ear swelling in mice,SO 2 induced cough in mice,expectorant experiment on phenolsulfon phthalein excretion and bacteria incubation in vitro,etc. Result:The total alkaloids of both FPA and FDA(ig,400mg·kg -1 and 200mg·kg -1 )have anti inflammatory,antibechic and expectorant effects,but the former is more effective than the latter.Given the same dosage,FPA is still more effective than FDA.FPA can inhibit Hemophilus influenzae, Staphylococcus aureus and Streptococcus pneumoniae,etc,more effectively than FDA.Conclusion:In anti inflammatory,antibechic,expectorant and bacteriostatic effects FPA is superior to FDA. [更多还原