【摘要】 目的　测定甲亢患者的骨密度与骨代谢生化指标 ,探讨甲亢骨质疏松发生的机理。方法　应用双能 X线测定仪 (DEXA) ,检查 6 1例甲亢患者骨密度 (BMD)的变化 ,同时测定血清骨特异性碱性磷酸酶 (B- ALP)、骨钙素 (BGP)、 型前胶原末端肽 (PICP)、抗酒石酸盐酸性磷酸酶 (TRAP)、尿吡啶啉(Pyd)、脱氧吡啶啉 (D- Pyd)的水平。结果　与对照组比较 ,甲亢患者的各项骨代谢生化指标均明显升高(P<0 .0 1) ,且与 FT4 呈正相关。结论　甲亢时反映成骨细胞活性的 B- AL P、BGP、PICP和反映破骨细胞活性的 TRAP、Pyd和 D- Pyd均升高 ,以破骨指标升高更明显 ,呈高转换型骨质疏松。更多还原

【Abstract】 Objective\ To investigate the mechanism and relationship between hyperthyroidism and osteoporosis.Methods\ Bone mineral density was observed using dual\|energy X\|ray absorptionmetry in 61 cases of hyperthyroidism, while serum bone specific alkaline phosphatase (B\|ALP), osteocalcin(BGP),carboxy terminal propeptied of type Ⅰ procollagen(PICP),tartrate\|resistant acid phosphatase (TRAP),pyridinoline (Pyd) and deoxy pydidinoline (D\|Pyd) level were were measured. Results \ Compared with control group,bone metabolic biochemical markers in all patients were significant increase. ( P <0 001) and there was positive correlation between FT 4 and markers of bone turnover.Conclusion\ The high levels of B ALP BGP and PICP indicating the activities of osteoblasts and TRAP,Pyd and D\|Pyd indicating those of osteoclasts are observed in patients with hyperthyroidism,especially Pyd and D\|Pyd,displaying high turnover osteoporosis.更多还原