【摘要】 目的 :探讨吡喃阿霉素 (THP)与大剂量碘油肝动脉栓塞化疗治疗不能手术切除原发性肝癌的方法和疗效。方法 :经皮肝动脉栓塞化疗 ,治疗组 146例 ,注入单次剂量为 6 0mg吡喃阿霉素和 2 0～ 6 0ml超化碘油 (Lipiodol)混悬液 ;对照组 188例 ,用 6 0mg表阿霉素和 5～ 19ml超化碘油。结果 :术后副作用不大 ,未见严重并发症。治疗组146例的 1、2、3年生存率为 71.2 %、39.4%、2 7.1% ;对照组 188例分别为 49.5 %、2 7.7%、2 0 .3% (P =0 .0 342 )。结论 :对ChildA级和ICGR 15小于 2 0 %的富血管型肝癌 ,THP与大剂量的碘油联合用药 ,绝大多数患者能够耐受 ,不会出现严重的并发症 ,且疗效优于常规的栓塞化疗更多还原

【Abstract】 Objective:To report the method and result of combining Pirarubicin(THP Adrmycin) and high dose lipiodol for treatment of unresectable hepatocellular carcinoma.Methods:From 1995 to 1998, 146 patients with unresectable hepatocellular carcinoma was treated with more than 20ml lipiodol of chemoembolization in our hospital.Results:The method of combining Pirarubicin and high dose lipiodol chemoembolization had a few side effect and a little hurt to the liver function. The 1 ,2 ,3 year survival rates of high dose lipiodol group were 71.2%、39.4%、27.1% respectively;and the 1 、2 、3 year survival rates of routine dosage were 49.5%、27.7%、20.3% respectively( P =0.0342).Conclusion:Combining Pirarubicin and high dose lipiodol chemoembolization for treatment of unresectable hepatocellular carcinoma is practically acceptable with the better result than the routine method. We suggest that the high dose lipiodol chemoembolization should be needed in patients with mass type hypervascular tumor located in right lobe whose ICG R15 must be less than 20% and Clhild classification for cirrhosis must be A.更多还原