【摘要】 目的 :　对 42例使用高三尖杉酯碱的急性白血病患者进行了临床药物动力学的研究 ,探索血药浓度及代谢动力学过程与疗效的关系。方法 :应用 HPL C测定患者血清中高三尖杉酯碱的血药浓度。结果 :高三尖杉酯碱在体内为二房室分布 ,药代动力学在不同个体间差异显著 ,与化疗疗效有关的参数是 K12 / K2 1,有效和无效组间差异非常显著 ,单独给药与联合用药组药代参数无显著差异。结论 :分析表明 K12 / K2 1与疗效呈负相关 (P<0 .0 1)更多还原

【Abstract】 Aim: To study the clinical pharmacokinetics of Homoharringtonine (HHT)in chemotherapy of acute leukemia (AL), Methods: The content of HHT in 42 cases of AL were determined. The correlation of potency and drug concentration in plasma and pharmacokinetic parameters were studied.Results:The distributive model of HHT in vivo was of two compartment. The pharmacokinetics in different patients were significantly different.The parameter K12/K21 related to the chemotherapeutic efficacy and with very significant difference between effective and non effective groups. There was no significant difference between single drug group and the drugs combination group.Conclusion:The results suggest that parameter K12/K21 correlates negatively with the potency of HHT.更多还原