【摘要】 目的　为了解慢性粒细胞白血病 (CML)骨髓中巨核细胞和网状纤维的增生情况及其关系。方法　观察33例CML患者的骨髓活检组织 (塑料包埋、HGF和Gomori染色 )的病理学改变。结果　发现所有患者的骨髓组织均存在网硬蛋白纤维增多 ,且随CML进展其程度加重 ;大多数患者巨核细胞过度增生 ,在CML不同阶段中巨核细胞数比较未见显著差异。结论　提示CML继发性的骨髓纤维组织增生主要与病情演进有关 ,并涉及巨核细胞的增生。更多还原

【Abstract】 Objective To determine the distribution of reticulin fibre and megakaryocyte in bone marrow biopsy(Trephine biopsy)of chronic myelogenous leukemia (CML).Methods The histopathological features were investigated in sections of embedded core biopsies of 33 patients with CML.Results The reticulin fibre proliferated in all specimen and most of them occured megakaryocytosis.The myelofibrosis was severer along with the progress of CML,while megakaryocyte counts didn′t change significantly.Conclusions Myelofibrosis secondary to CML is mainly related to its clinical stage and implicated megakaryocytosis. [更多还原