【摘要】 目的　研究胃癌组织中p5 3和P 糖蛋白表达的意义。方法　应用SP免疫组织化学的方法对 98例胃癌进行检测。结果　在 98例胃癌中 ,5 9.8%的 p5 3表达阳性 ,5 7.1%的P 糖蛋白表达阳性。p5 3和P 糖蛋白与胃癌的分化程度和生存期限有关 (P <0 .0 5 )。p5 3还与胃癌的浸润程度 ,淋巴结转移情况有关。P 糖蛋白表达阳性者 ,在 p5 3表达阳性组 ,明显高于 p5 3表达阴性组。 结论　联合检测 p5 3蛋白和P 糖蛋白对胃癌的诊断、治疗和预后有重要意义更多还原

【Abstract】 ? Objective To study the clinical significance of p53 protein and P glycoprotein expression in gastric carcinoma tissue.Methods The expression of p53 protein and P glycoprotein in 98 gastric carcinoma was studied with S P immunohistochemical technique.Results Positive expression of p53 protein was 59.8% in 98 gastric carcinoma and positive expression of P glycoprotein was 57.1%.A significant correlation was found between p53 protein,P glycoprotein and some data such as differentiated degree and 5 years survival ratio(P<0.05).P53 was also found correlating with invased depth of lymph node metastases,P glycoprotein was higher in those with positive p53 than those with negative p53.Conclusions The determination of p53 and P glycoprotein may be useful for diagnosis,treatment and prognosis of gastric carcinoma. 〔更多还原