【摘要】 目的:对卡铂非离子表面活性剂泡囊的制备工艺进行考察，并评价其质量。方法:用薄膜分散法制备卡铂非离子表面活性剂泡囊，并对其形态学、包封率、pH值和表面电荷等性质进行了研究。结果:卡铂非离子表面活性剂泡囊球形圆整，大小较均匀，算术平均径为3.26 μm，包封率为29.16%，pH值为6.4，电性呈中性。结论:非离子表面活性剂泡囊的制备工艺对其质量有较大影响，以非离子表面活性剂为载体材料制备卡铂泡囊是可行的，选择薄膜分散法优化工艺制备得到的卡铂非离子表面活性剂泡囊，包封率较高。更多还原

【Abstract】 OBJECTIVE：To study the preparation of Carboplatin entrapped niosome (CBP NS) and evaluate its quality.METHODS：The noisomes were prepared by hand shaking method.The morphology of CBP NS,the entrapment efficiency and the pH were studies.RESULTS：The niosomes were spherical with size of 2.0～10.0 μm and the extent of entrapment of CBP NS was 29.16%.The pH was 6.4.CONCLUSIONS：The technology of preparation of non ionic surfactant carboplatin vesicles is practicable and successful.更多还原