【摘要】 目的 :制备依托泊苷白蛋白微球 ,并对其形态学性质、载药量、体外释药特性进行研究。方法 :用乳化热固化法制备依托泊苷白蛋白微球。结果 :微球平均粒径 (1 3.6 1± 4.80 ) μm ,含药量为 (1 8.2 5± 0 .1 8) % ,药物包封率为 (45 .45± 1 .2 7) % ,体外释药符合Higuchi方程 :Q =0 .0 1 5 91 +0 .0 9837t1/2 (r =0 .9975 )。结论 :用乳化热固化法制备的依托泊苷白蛋白微球外观圆整 ,载药量较高 ,体外释药符合长效制剂特征。更多还原

【Abstract】 OBJECTIVE:To prepare the etoposide bovine serum albumin microspheres (VP BSA MS) and to study the properties of its morphology,drug loading and release in vitro .METHODS:The VP BSA MS was prepared by emulsion heat stabilization techniques.RESULTS:The mean diameter of VP BSA MS was (13.61±4.80) μm.The drug loading was (18.25±0.18)% and the embedding ratio was (45.45±1.27)%.The in vitro release properties of VP BSA MS could be expressed by the Higuchis equation:Q=0.01591+0.09837t 1/2 (r=0.9975).CONCLUSION:The VP BSA MS prepared by emulsion heat stabilization techniques was regular in its morphology with a high drug loading and in vitro release properties conformed to long acting preparations.更多还原