【摘要】 目的 :观察异丙酚与芬太尼联合持续静脉输注用于 ICU镇静的作用。方法 :对 30例腹部手术后机械通气病人给予异丙酚与芬太尼联合 (10 0∶ 0 .1)持续静脉输注。结果 :总镇静时间为 (2 3.3± 11.7) h,其中满意镇静时间占 (90 .1± 8.3) % ,异丙酚总平均静注速度为 (6 .5± 3.1) μg· kg- 1· m in- 1 ,满意镇静期间的平均静注速度为(5 .5± 2 .7) μg· kg- 1· m in- 1 ,镇静期间心率平稳 ,血压略降但维持稳定。停止镇静后病人完全清醒时间为 0～ 2 0min,脱离呼吸机时间为 (19.5± 16 .9) m in,拔气管导管时间为 (6 6 .3± 2 3.3) min,拔气管导管后 30 min血气正常。结论 :芬太尼与异丙酚联合用于 ICU病人镇静效果满意 ,并可以明显减少异丙酚用量。更多还原

【Abstract】 Objective:Our purpose was to observe the combine effect of propofol and fentanyl on patients with mechanical ventilation. Methods: Propofol and fentanyl were given by continuous infusion to provide sedation in 30 adult patients who required mechanical ventilation after abdominal operation. Results: The total duration of propofol sedation was (23.3±11.7) hours. Satisfactory sedative time (Ramsay sedation level 2-5) was (90.1± 8.3 )% of the total sedative period. The average infusion rate of propofol during the total sedative period was ( 6.5 ±3.1)μg·kg -1 ·min -1 ,it was (5.5±2.7) μg· kg -1 ·min -1 during the satisfactory sedative period, the heart rate of the patients remained unchanged, while blood pressure decreased slightly. The time from the end of infusion of propofol to total recovery of consciousness was 0 to 20 minutes. The time from the end of infusion of propofol to weaning from ventilator and to extubation were (19.5±16.9) and (66.3±23.3) minutes respectively and blood gas was normal in 30 minutes after extubation. Conclusion: Propofol and fentanyl have a remarkable coeffect, thus can be used together in the mechanical ventilation patients and this combination can reduce propofol dosage greatly.更多还原