【摘要】 目的 :研究肝硬化合并原发性肝癌、原发性肝癌、肝硬化及正常人血清转化生长因子 -α(transforminggrowth factor- α,TGF- α)变化 ,探讨 TGF- α在肝硬化合并原发性肝癌中的临床意义。方法 :肝硬化合并原发性肝癌48例 ,原发性肝癌 30例 ,肝硬化 80例 ,正常对照组 5 0例 ,采用放免法检测血清 TGF- α。结果 :血清 TGF- α含量在肝硬化合并原发性肝癌时明显高于肝硬化组及正常对照组 ,P <0 .0 1;原发性肝癌血清 TGF- α含量明显高于肝硬化及正常对照组 ,P <0 .0 1;肝硬化合并原发性肝癌血清 TGF-α含量与原发性肝癌血清 TGF-α含量无显著差异 ,P >0 .0 5。结论 :血清 TGF-α含量在肝硬化合并原发性肝癌及原发性肝癌时均明显增高 ,因此 TGF-α血清含量测定是诊断原发性肝癌 ,特别是肝硬化合并原发性肝癌的有价值的标志物。更多还原

【Abstract】 Objective:To study the alteration of TGF α in the sera of the patients with hepatic carcinoma accompanied with cirrhosis the patients with primary hepatic carcinoma, the patients with hepatic cirrhosis, and the normal persons. To elucidate the value of TGF α in the diagnosis of hepatic cirrhosis accompanied with PHC. Methods:Using radioimmunological method to fest TGF α in serum of 48 patients of hepatic cirrhosis accompanied with primary hepatic carcinoma, 30 patients of primary hepatic carcinoma, 80 patients of hepatic cirrhosis, and 50 patients of normal persons.Results: The contents of TGF α in the sera of patients with hepatic cirrhosis accompanied with primary hepatic carcinoma and of patient with the latter alone was significantly higher those that of patients with hepatic cirrhosis (P<0.01) and of normal persons (P<0.01). Sera TGF α did not differ between two groups of primary hepatic carcinoma (P>0.05). Conclusion: The content of serum TGF α increases significantly in the primary hepatic carcinoma. So the determination of serum TGF α is a valuable marker of primary hepatic carcinoma especially of hepatic cirrhosis accompanied with primary hepatic carcinoma.更多还原