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慢性乙型肝炎患者血清可溶性Fas测定及其临床意义
Clinical significance and detection of serum soluble Fas in patients with chronic viral hepatitis B
【摘要】 目的 :检测慢性乙型肝炎患者血清可溶性Fas (sFas)水平 ,并探讨其在肝炎发病机理中的作用和临床意义。方法 :用ELISA法检测了 42例慢性乙型肝炎和 2 0例正常人血清sFas浓度。结果 :慢性乙型肝炎患者血清sFas浓度为 (6 1± 3 4)ng/ml,明显高于正常对照组 (t =2 463 ,P <0 0 1 )。PCR -HRV -DNA阳性组与PCR -HBV -DNA阴性组血清sFas无显著性差异。sFas与多项肝炎活动程度指标呈正相关。结论 :血中sFas在慢性乙型肝炎发病过程中可能起着重要作用 ,检测病人血中sFas水平可作为慢性乙型肝炎疾病活动性指标。
【Abstract】 Objective:To investigate the pathogenesis and clinical evaluation for detection of serum soluble Fas (sFas) in patients with chronic viral hepatitis B.Methods:Serum sFas was detected in 42 patients with chronic hepatitis B and 20 normal controls by ELISA.Results:The patients with chronic hepatitis B showed higher levels of serum sFas than normal controls (t=2.463,P<0.01).Serum sFas levels in chronic hepatitisis B was positively related to hepatitis disease activity parameters.Conclusions:Increased serum sFas might play an important role in the development of chronic viral hepatitis B.Serum sFas levels might serve as an active index for chronic hepatitis B.
- 【文献出处】 中国冶金工业医学杂志 ,Chinese Medical Journal of Metallurgical Industry , 编辑部邮箱 ,2000年06期
- 【分类号】R512.6
- 【下载频次】10