【摘要】 用 1日龄雏鸡免疫评价了鸡大肠杆菌多价 1型菌毛油乳剂苗在鸡体内的免疫原性。用含 1型菌毛的 3个不同血清型 (O1、O78及O88)菌株 ,大容量培养后提取菌毛制备多价菌毛油乳剂苗。接种多价菌毛油乳剂苗的鸡用同源菌株攻毒后出现 10 %～ 11.2 %的死亡率 ,阳性对照组鸡攻毒后出现 70 %～ 80 %的死亡率 ;用异源菌株 (O36)攻毒后 ,免疫鸡出现 33.3%的死亡率 ,而未免疫阳性对照组鸡死亡率达 70 %。免疫鸡在气囊 ,心包及肝脏的病变非常轻微 ,且攻毒后比非免疫鸡能更有效地清除侵入气囊的大肠杆菌更多还原

【Abstract】 Immunogenicity of avian Escherichia coli multivalent tpye 1 pilus vaccine was evaluated in one_day_old chickens.Three different serotype(O1,O78 and O88)strains containing type 1 pili were cultivated largely for preparing the multivalent pili oilemulsion vaccine.Vaccinated chickens suffered 10% to 11.2% mortality after challenged with homologous Escherichia coli,positive control group suffered 70% to 80%mortality;and suffered 33.3% mortality after challenged with heterologous Escherichia coli,its positive control group suffered 70% to 80% mortality.vaccinated chickens had very mild gross lession in the air sacs,liver and pericardial sacs and eliminated Escherichia coli more efficiently than the unvaccinated chickens.更多还原